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KMID : 0892720080120010001
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Journal of the Korean Society of Maternal and Child Health
2008 Volume.12 No. 1 p.1 ~ p.7
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Efficacy of Human Papillomavirus Vaccines as an Anticancer Vaccine
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Seo Kyung
Shin Hai-Rim
Oh Jin-Kyoung
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Abstract
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Objectives: Aim of study is to review efficacies of two human papillomavirus vaccines in different study populations and examine importance of HPV vaccine as a routine vaccine.
Methods: Four phase-3 efficacy studies of two HPV vaccines were reviewed. Magni-tude of efficacies were compared among different study populations.
Results: Recently, two kinds of papillomavirus (HPV) vaccines were developed. "Cer-varix" is a bivalent vaccine which contained L1 protein of HPV 16 and HPV 18, and "Gardasil" is a quadrivalent vaccine which contained L1 protein of HPV 6 and HPV 11 in addition. Efficacy study showed that both vaccine are highly effective to prevent cer-vical, vaginal and vulvar precancerous lesion in the population who are naive to HPV in-fection. Quadrivalent vaccine also showed high efficacy to prevent genital warts. Efficacy of the vaccine decreased in the general population who included both HPV-naive and HPV-infected peoples. Both vaccines showed high immune responses for 5 years after vaccination.
Conclusions: From the point of public health, HPV vaccine is an important vaccine for young adolescents who have not begun sexual activity. However, development of guide-lines for HPV vaccination for each country will be dependent on cost effectiveness of HPV vaccines of each population.
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KEYWORD
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humanpapillomavirus, vaccine, efficacy
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